Dr Neil Gittoes Consultant Endocrinologist
Dr Neil GittoesConsultant Endocrinologist

Research

From 1995 - 2008 Dr Gittoes pursued a successful academic career.

In 2008 he moved to the NHS to take on a senior leadership role. He continues to be highly active in research and teaching.

 

Since 2016 and his appointment as Honorary Professor of Endocrinology, he has also been Head of the Centre for Endocrinology, Diabetes and Metabolism in the Institute of Metabolsim and Systems Research at the University of Birmingham. 

 

Some of his academic achievements are highlighted below.

Recent publications

Peer reviewed publications

 

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  • Hassan-Smith Z, Gittoes NJL, Hewison M. 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression. PLOS ONE, IN PRESS.
  • Harborne K, Hazlehurst JM, Shanmugaratnam H, Pearson S, Doyle A, Gittoes NJL, Choudhary S, Crowley RK. Compliance with established guidelines for the radiological reporting of atypical femoral fractures. British Journal of Radiology, 2016 Jan;89(1057):20150443. doi: 10.1259/bjr.20150443. Epub 2015 Oct 28.
  • Shipman K, Stammers J, Doyle A, Gittoes NJL. Delivering a quality assured fracture liaison service in a UK teaching hospital - is it achievable? In press Osteoporosis International 2016. May 18. [Epub ahead of print]; PMID: 27193285
  • Tampourlou M*, Ntali G*, Ahmed S, Arlt W, Ayuk J, Byrne JV, Chavda S, Cudlip S, Gittoes N, Grossman A, Mitchell R, O’ Reilly M, Paluzzi A, Toogood A, Wass JAH, Karavitaki N, The outcome of patients with regrown non-functioning pituitary adenoma after primary treatment - further tumour progression and risk factors: a retrospective cohort study from two large UK specialist centres. Journal of Clinical Endocrinology and Metabolism, IN PRESS

  • Sanderson J, Martyn-St James M, Stevens J, Goka E,  Wong R, Campbell F, Stevenson M, Selby P, Gittoes NJ, Davis S. Clinical effectiveness of bisphosphonates for the prevention of fragility fractures:  a systematic review and network meta-analysis. Bone 2016. Jun 1. pii: S8756-3282(16)30149-1. doi: 10.1016/j.bone.2016.05.013. [Epub ahead of print]; PMID: 27262775
  • O'Reilly MW, Reulen RC, Gupta S, Thompson CA, Dineen R, Goulden EL, Bugg G, Pearce H, Toogood AA, Gittoes NJ, Mitchell R, Thompson CJ, Ayuk J. ACTH and gonadotropin deficiencies predict mortality in patients treated for nonfunctioning pituitary adenoma: long-term follow-up of 519 patients in two large European centres, Clinical Endocrinology (Oxf). 2016 Jun 21.doi:10.1111/cen.13141. [Epub ahead of print] PMID: 27327840
  • Chauhan P, Gittoes NJ, Geberhiwot T. Successful treatment of recurrent renal stones with Cinacalcet in a patient with primary hyperparathyroidism. BMJ Case Rep. 2016 Aug 12;2016. pii: bcr2016216311. doi: 10.1136/bcr-2016-216311. PMID: 27520998
  • Davis S, Martyn-St James M, Sanderson J, Stevens J, Goka E, Rawdin A, Sadler S, Wong R, Campbell F, Stevenson M, Strong M, Selby P, Gittoes NJ. A systematic review and economic evaluation of bisphosphonates for the prevention of fragility fractures. Health Technology Assessment. 2016 Oct; 20(78):1-406. PMID: 27801641
  • Walsh J, Gittoes NJ, Selby P, Society for Endocrinology Clinical Committee. SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE: Emergency management of acute hypercalcaemia in adult patients. Endocrine Connections. 2016 Sep;5(5):G9-G11. No abstract available. PMID: 27935816
  • Turner J, Gittoes NJ, Selby P; Society for Endocrinology Clinical Committee. SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE: Emergency management of acute hypocalcaemia in adult patients. Endocrine Connections. 2016 Sep;5(5):G7-G8. No abstract available. PMID: 27935815
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  • Tampourlou M*, Ntali G*, Ahmed S, Arlt W, Ayuk J, Byrne JV, Chavda S, Cudlip S, Gittoes N, Grossman A, Mitchell R, O’ Reilly M, Paluzzi A, Toogood A, Wass JAH, Karavitaki N, The outcome of patients with regrown non-functioning pituitary adenoma after primary treatment - further tumour progression and risk factors: a retrospective cohort study from two large UK specialist centres. Journal of Clinical Endocrinology and Metabolism, IN PRESS

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  • Enclosing a pen reduced time to response to questionnaire mailings. Bell K, Clark L, Fairhurst C, Mitchell N, Lenaghan E, Blacklock J, Cushnaghan J, Cooper C, Gittoes N, O'Neill TW, Shepstone L, Torgerson DJ; SCOOP Study Team. J Clin Epidemiol. 2015 Dec 29. pii: S0895-4356(15)00580-6. doi: 10.1016/j.jclinepi.2015.12.004. [Epub ahead of print]
  • Vitamin D - what is normal according to latest research and how should we deal with it? Gittoes NJ. Clin Med (Lond). 2015 Dec;15 Suppl 6:s54-7. doi: 10.7861/clinmedicine.15-6-s54.
  • Compliance with established guidelines for the radiological reporting of atypical femoral fractures. Harborne K, Hazlehurst JM, Shanmugaratnam H, Pearson S, Doyle A, Gittoes NJ, Choudhary S, Crowley RK. Br J Radiol. 2016 Jan;89(1057):20150443. doi: 0.1259/bjr.20150443. Epub 2015 Oct 28.
  • Difficult access in the anaesthetic room leads to a difficult diagnosis. Crabtree S, Lowry D, Tiwari A, Gittoes N. BMJ. 2015 Jul 8;351:h3430. doi: 10.1136/bmj.h3430.
  • National Osteoporosis Society practical clinical guideline on vitamin D and bone health. Francis RM, Aspray TJ, Bowring CE, Fraser WD, Gittoes NJ, Javaid MK, Macdonald HM, Patel S, Selby PL, Tanna N. Maturitas. 2015 Feb;80(2):119-21. doi: 10.1016/j.maturitas.2014.11.018. Epub 2014 Nov 27.
  • Fear of medication side effects is a barrier to optimal osteoporosis care. Sheltawy AA, Criseno S, Gittoes NJ, Crowley RK. Osteoporos Int. 2015 Feb;26(2):843-4. doi: 10.1007/s00198-014-2922-z. Epub 2014 Oct 22.
  • National Osteoporosis Society vitamin D guideline summary. Aspray TJ, Bowring C, Fraser W, Gittoes N, Javaid MK, Macdonald H, Patel S, Selby P, Tanna N, Francis RM; National Osteoporosis Society. Age Ageing. 2014 Sep;43(5):592-5. doi: 10.1093/ageing/afu093. Epub 2014 Jul 28.
  • Green AE, Sherlock M, Stewart PM, Gittoes NJL, Toogood AA. (2014), Extensive experience in the management of prolctinomas, Clin Endocrinol. Jan 31, EPUB Ahead of Print. PMID 24483350.  
  • Manolopoulos KN, West A, Gittoes NJL. (2013), The paradox of prevention--bilateral atypical subtrochanteric fractures due to bisphosphonates in osteogenesis imperfecta, J Clin Endocrinol Metab. 2013 Mar;98(3):871-2.
  • Shepstone L, Fordham R, Lenaghan E, Harvey I, Cooper C, Gittoes NJL, Heawood A, Peters T, O'Neill T, Torgerson D, Holland R, Howe A, Marshall T, Kanis J, McCloskey E. (2012) A pragmatic randomised controlled trial of the effectiveness of screening older women for the prevention of fractures: rationale, design and methods for the SCOOP study, Osteoporos Int. 2012 Oct;23(10):2507-15.
  • Patel P, Hardy R, Sumathi V, Bartle G, Kindblom L-G, Grimer R, Bujalska I, Stewart PM, Rabbitt E, Gittoes NJL, Cooper MS. (2012) Expression of 11b-Hydroxysteroid Dehydrogenase Enzymes in Human Osteosarcoma: Potential Role in Pathogenesis andas Targets for Treatments, Endocrine Related Cancer, 19 (4), 589-598.
  • Nirmalan A, Anderson M, Ferner RE, Gittoes NJL. (2011) Hypomagneseamia and seizures. Clinical Medicine, 11 (6), 591-593.
  • Harries A, Gittoes NJL, Mitchell R. (2010) Resolution of 3rd nervepalsy following treatment of prolactinoma with cabergoline. Acta Neurochirurgica, 152, 1741-1743.
  • Crabtree NJ, Bebbington NA, Chapman DM, Wahid YS, Ayuk J, Boivin CM, Cooper MS, Gittoes NJL. (2010) Impact of UK National guidelines based on FRAX® - Comparison with current clinical practice. Clinical Endocrinology, 73, 452-456.
  • Mukhopadhyay R, Strens LH, Winer JB, Ayuk JA, Gittoes NJL. (2010)Having the vision to measure calcium. Journal of Neurology, Jun, 257 (6), 1032-4.
  • Langston AL, Campbell MK, Fraser WD, MacLennan GS, Selby PL, Ralston SH; PRISM Trial Group. (2010) Randomized trial of intensive bisphosphonate treatment versus symptomatic management in Paget's disease of bone. Journal of Bone and Mineral Research, 25(1), 20-31.

Review articles

  • Crowley R, Gittoes NJL (2014) When would I use medical therapies for the treatment of primary hyperparathyroidism? Clin Endocrinol (Oxf). 2013 Dec;79(6):770-3.
  • Ayuk JA, Gittoes NJL. (2014) Contemporary View of the Clinical Relevance of Magnesium Homeostasis, Annals of Clinical Biochemistry, Am J Kidney Dis. 2014 Apr;63(4):691-5.
  • Crowley R, Gittoes NJL. (2013) How to approach hypercalcaemia, Clin Med. Jun;13(3):287-90. 
  • Ayuk JA, Gittoes NJL. (2011) How should hypomagnesaemia be investigated and treated? Clinical Endocrinology 75 (6), 743-746.
  • Ayuk JA, Cooper MS, Gittoes NJL. (2010) New Perspectives in the Management of Primary hyperparathyroidism, Therapeutic Advances in Endocrinology and Metabolism 1 (5), 197-206.
  • Cooper MS, Gittoes NJL. (2010) Bone health and thyroid disease, OsteoporosisReview, 18 (4), 1-7.
  • Gittoes NJL, Cooper MS. (2010) Bone as an endocrine organ, Osteoporosis Review 18 (3), 20-23.
  • Cooper MS, Gittoes NJL. (2010) Primary hyperparathyroidism – Is mild disease worth treating? Clinical Medicine 10 (1), 45-49.
  • ToozeA, Gittoes NJL, Jones CA, Toogood AA. (2009) Neurocognitive consequences of surgery and radiotherapy for tumours of the pituitary, Clinical Endocrinology 70(4), 503-511.
  • Cooper MS, Gittoes NJL. (2008) Diagnosis and Management of Hypocalcaemia, British Medical Journal 336 (7656), 1298-1302.

 

Chapters in books

  • Gittoes NJL. (IN PRESS) Hypocalcaemia, In: Oxford Desktop Reference, eds., Eastell R, Oxford University Press, Oxford.
  • Ayuk JA, Gittoes NJL. (2014) Management of Hyperparathyroidism, In: Otorhinolaryngology and Head and Neck Surgery, eds., Watkinson JA, Clark R, Scott Brown.
  • Gittoes NJL. (2014) Calcium & Bone Metabolism, Section editor and reviewer, In: Oxford Handbook of Endocrinology and Diabetes, 3rd edition, eds., Wass JAH, Turner HE, Oxford University Press, Oxford.
  • Cooper MS, Gittoes NJL. (2013) Hypocalcaemia, In: Tarascon Adult Endocrinology Pocketbook, eds., Laufgraben M, Gopalakrishnan G, Jones & Bartlett Learning, Sudbury, MA.
  • Ayuk JA, McCabe CJ, Gittoes NJL. (2011) Pituitary Carcinoma. In: Oxford Textbook of Endocrinology and Diabetes, 2nd ed., Oxford University Press, Oxford.
  • Gittoes NJL, Ayuk J and Ferner R. (2011) Diabetes Secondary to Drug Therapy. In: Textbook of Diabetes, 4th Edition, eds., Holt R, Flyvjberg A, Goldstein B, Cockram C, Wiley-Blackwell, Scientific Publications, London.
  • Kim D, Gittoes NJL. (2011) Endocrine Disease: Molecular Biology and Genetic Testing. In: Textbook of Head and Neck Surgery and Oncology, 5th edition, eds., Watkinson JC, Gilbert R, Stell and Maran's.

Major grants

1. Thyroid hormone receptor expression and function in "non-functioning" pituitary tumours. Medical Research Council, Career Establishment Grant, £310 305, 1998 (5 years).

2. Pretranslational expression of nuclear steroid receptors and pituitary tumour transforming gene (PTTG) in human pituitary adenomas. Medical Research Council, Equipment Grant for £73 368, 1999.

3. Pre-receptor regulation of glucocorticoids and the control of pituitary cell proliferation: a novel target for tumour therapy. The United Birmingham Hospitals Endowment Fund grant for post-doctoral fellow, £59 979, 2001 (2 years). Extension 5 months £11,044.

4. Pre-receptor metabolism and the control of hormone action. Medical Research Council Cooperative Group Grant, £345 982 2002 (5 years)

5. Pituitary radiotherapy as a risk factor for cerebrovascular disease and neurocognitive
dysfunction. The United Birmingham Hospitals Endowment Fund grant for post-doctoral fellow, £49 959, 2004 (2 years)

6. Genetics service for patients in primary and secondary care (endocrinology section). Department of Health, Funds for staff and service development, £1 800 000, 2004

7. A pragmatic randomised controlled trial of screening for osteoporosis in older women. Medical Research Council Health Technology Assessment grant, £4 280 273 + £4 750 985 NHS costs, 2006 (7 years)

8. Osteoporosis and growth hormone nurse salary support, Eli Lilly, £37 607, 2007 (1 year)

9. The role of intracellular glucocorticoid metabolism in osteosarcoma pathogenesis. The United Birmingham Hospitals Endowment Fund grant for technician, £49 732, 2007 (2 years)

10. Osteogenesis imperfecta: surveys of disease complications and the effects of treatment. The United Birmingham Hospitals Endowment Fund grant for research nurse, £69 589, 2011 (2 years)

11. Understanding the molecular mechanism of bone disease in Gaucher patients. Shire Pharmaceuticals funding for Clinical Research Fellow, £195,000, 2012, (3 years)

12. Phase II study of the impact of a selective 11beta-HSD1 inhibitor on biochemical
markers of bone turnover in post-menopausal osteopaenia, MRC-AZ, £360,000, 2013, (2 years)

Invited talks

Royal College of Physicians Endocrine Teach In, London, UK

12/2015

Chair and lecture

Glucocorticoid effects on bone

Irish Assembly and National Osteoporosis Society

06/2015

Lecture

Personal and societal impact of osteoporosis

Annual Meeting of the British Endocrine Societies, Edinburgh, UK

10/2015

Lecture

What to do after bisphosphonate treatment

West Midlands Physicians Association

05/2015

Lecture

Vitamin D – hype or substance?

Royal Society of Medicine, Head and Neck Tumour Conference

03/2015

Lecture

Investigation and assessment of pituitary tumours

Royal College of Physicians Advanced Medicine Course, London, UK

 

02/2015

Lecture

Endocrine and non-classical actions of vitamin D

National Osteoporosis Society Conference, Birmingham

12/2014

Workshop

Commissioning high quality osteoporosis services

National Launch Public Health England and NICE – Vitamin D Guidelines, Nottingham

11/2014

Lecture

Vitamin D in bone diseases and public health

National Osteoporosis Society Conference, Birmingham

12/2014

Lecture

Calcium abnormalities and how to approach them

West of Scotland Bone Interest Group

10/2014

Lecture

Emerging therapies in osteoporosis

London Grand Rounds Annual Meeting St Bartholomew’s Hospital, London

10/2104

Lecture

Calcium disorders on the oncology ward

Masterclass in fracture prevention, Manchester

09/2014

Lecture

Delivering the standards in fracture liaison services

Annual Meeting of the British Endocrine Societies, Harrogate, UK

03/2014

Lecture

Osteogenesis imperfecta

Annual Meeting of the British Endocrine Societies, Harrogate, UK

03/2014

Chair and lecture

Vitamin D – Who, when and how to treat?

  • Vitamin D - All hype and no substance? Society for Endocrinology and Scottish Endocrine Society, Dundee, May 2014
  • Vitamin D Meet the Professor Chairman, British Endocrine Societies Annual Meeting, Manchester, March 2014.
  • Vitamin D and Advances in Osteoporosis, Jersey Medical Update, St Helier, December 2013.
  • Managing Primary Hyperparathyroidism, Society for Endocrinology & Welsh Endocrine Society Clinical Cases Meeting, Newport, May 2013
  • Hypocalcaemia - How to assess and treat, Royal College of Physicians of Ireland, Dublin, December 2012.
  • Non-functioning Pituitary Tumours and Prolactinomas – Update on Management, Annual Diabetes and Endocrinology Conference, Royal College of Physicians of Edinburgh, Edinburgh, October 2012.
  • Vitamin D Treatment – Searching for Clarity Amongst Confusion, Fife Osteoporosis National Conference, Fife, September 2012.
  • Bones, Fractures, Healing and Health, Cheltenham Science Festival, Cheltenham, June 2012.
  • Preventing Fractures in the Elderly, British Geriatric Society Conference, Llandudno, May 2012
  • Vitamin D – Need for Guidance, Irish Endocrine Group, Cork, Ireland, May 2012
  • Vitamin D Deficiency in the Middle East, Advanced General Medicine Conference, Royal College of Physicians, Muscat, Oman, February 2012
  • Thyrotoxicosis – International Update, Advanced General Medicine Conference, Royal College of Physicians, Muscat, Oman, February 2012
  • Update on Thyrotoxicosis, British Thyroid Foundation Patient support Group, Birmingham, November 2011
  • Clinical Relevance of RANK Ligand Inhibition, Welsh National Bone Academy, Newport, September 2011

Contact details

Professor Neil Gittoes (NHS/Univ)

Department of Endocrinology

Queen Elizabeth Hospital

Edgbaston

Birmingham

B15 2TH

 

www.uhb.nhs.uk

www.birmingham.ac.uk

 

NHS Secretary

Tel 0121 371 6940

Fax 0121 371 6941

 

Professor Neil Gittoes (Private)

BMI The Priory Hospital

Edgbaston

Birmingham

0121 446 1638

 

and

 

BMI The Droitwich Spa Hospital

St Andrews Road

Droitwich Spa

Worcestershire

WR9 8DN

01905 793316

 

Professor Gittoes at BMI Priory & Droitwich

 

Private Secretary     secretarymeol@btinternet.com

Tel 07896890508

Fax 01386 792492

News on Twitter

Useful links and patient resources

You and Your Hormones - Resource of the Society for Endocrinology providing detailed patient focussed information on endocrine diseases.

 

National Osteoporosis Society - Detailed coverage of osteoporosis and related bone diseases.

 

Brittle Bone Society - Patient focussed resource for those with brittle bone disease or osteogenesis imperfecta.

 

Hypoparathyroidism UK - Coverage of parathyroid diseases for patients.

 

Paget's Association - Information for patients with Paget's disease of bone.

 

British Thyroid Foundation - Patient support group for those with thyroid disease, backed by the British Thyroid Association.

 

Pituitary Foundation - Broad coverage of all aspects of pituitary disease with a major patient focus.

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